Dengue virus is known to cause low platelet count in blood of patient by : 1. interfering in the process of platelet production in bone marrow 2. infecting endothelial cells 3. binding with platelets 4. accumulating platelets in intestine Select the correct answer using the code given below :

Dengue virus causes thrombocytopenia (low platelet count) through multiple mechanisms. First, the virus interferes with platelet production by directly infecting hematopoietic progenitor cells and megakaryocytes in the bone marrow, leading to bone marrow suppression [3]. Second, the virus infects endothelial cells, which increases vascular permeability and promotes platelet-endothelial interactions, leading to increased consumption [3]. Third, the virus binds directly to platelets and induces immune-mediated destruction; anti-platelet antibodies and viral antigens bind to the platelet surface, causing their clearance by the immune system [3]. There is no established scientific evidence for the accumulation of platelets in the intestine as a primary mechanism for low platelet count in dengue. Therefore, statements 1, 2, and 3 are correct, making option 4 the right choice.

Sources

1. [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC11488332/
2. [3] https://pmc.ncbi.nlm.nih.gov/articles/PMC4427128/
3. [2] https://pmc.ncbi.nlm.nih.gov/articles/PMC4270245/