Which of the following statements about vitamins are correct? 1. Vitamin C is essential to make connective tissue in body. 2. Vitamin D is needed for synthesis of eye pigment. 3. Vitamin B12 helps in maturation of RBC. 4. Vitamin C is required to make use of calcium absorbed from the intestine. Select the correct answer using the code given below.

Statement 1 is correct as Vitamin C (ascorbic acid) is a vital cofactor for enzymes like prolyl hydroxylase, which are essential for collagen synthesis and the formation of stable connective tissues [1]. Statement 2 is incorrect because Vitamin A, not Vitamin D, is required for the synthesis of rhodopsin (visual purple), the light-sensitive pigment in the eye [2]. Statement 3 is correct; Vitamin B12 (cobalamin) is essential for DNA synthesis and the proper maturation of red blood cells (erythropoiesis) [2]. Statement 4 is incorrect because Vitamin D, not Vitamin C, is the primary nutrient required to facilitate the absorption and utilization of calcium from the intestine. While Vitamin C is involved in bone matrix formation, it does not regulate intestinal calcium absorption. Therefore, only statements 1 and 3 are accurate.

Sources

1. [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC6204628/
2. [2] https://www.nature.com/articles/s41598-020-72704-1