With reference to normal human beings consider the following statements: 1. In response to the presence of HCL, secretian is produced from the duodenum 2. Enterogastrone is produced in the small intestine in response to the presence of fatty acids Which of these statements is/are correct?

Both statements are correct. Secretin is produced by S cells in the duodenal mucosa in response to acidic gastric chyme (HCl) entering the duodenum and acts to stimulate pancreatic and biliary bicarbonate secretion while inhibiting gastric acid and motility [2]. The term “enterogastrone” refers to intestinal hormones that inhibit gastric secretion and motility in response to luminal fats; fatty acids in the small intestine elicit such enterogastrone activity (historically attributed to duodenal hormones that slow gastric activity in the presence of fats) [3]. Thus secretin is acid-responsive in the duodenum, and enterogastrone-type responses are produced by the small intestine to fatty acids, inhibiting gastric function [3].

Sources

1. [1] https://www.ncbi.nlm.nih.gov/books/NBK537284/
2. [2] https://www.ncbi.nlm.nih.gov/books/NBK537116/
3. [3] https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/gastrointestinal-hormone